Castiglione del Lago is reached:

Highway (A1) Florence-Rome:
Valdichiana exit for those arriving from the north, exit Chiusi-Chianciano Terme for those coming from the south.

Railway Milan-Florence-Rome:
Station of Castiglione del Lago, or Chiusi or Terontola and successive automotive connection.

Ancona Railway Terontola-Foligno:
Terontola with subsequent connection by car.